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By Hooper N.M. (ed.)

This article brings jointly the most ideas of biochemistry, cellphone biology, and molecular biology which are getting used to enquire the molecular foundation of Alzheimer's illness. It presents a precis of at present on hand healing brokers and clients for destiny medicines.

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17. 18. 19. 20. 21. 22. 23. 37 and late-onset cases, and among male and female relatives in successive generations. Neurology 38, 207–212. van Duijn, C. , Chandra, C. , Fratiglioni, L, Graves, A. , et al. (1991) Familial aggregation of Alzheimer’s disease and related disorders: a collaborative re-analysis of case control. studies. Int. J. Epidemiol. 20(suppl. 2), S13–S20. Yatham, L. , McHale, P. , and Kinsella, A. (1988) Down’s syndrome and its association with Alzheimer’s disease. Acta. Psychiatr.

Neurology 40, 395–403. Pericak-Vance, M. , Bass, M. , Yamaoka, L. , Gaskell P. , Scott, W. , Terwedow, H. , et al. (1997) Complete genomic screen in late onset familial Alzheimer’s disease. Evidence for a new locus on chromosome 12. JAMA 278, 1237–1241. , Song, Y. , et al. (1998) Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. JAMA 280, 614–618 Wu, W. , et al. (1998) Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA 280, 619–622.

1998) Butyrylcholinesterase K variant (BCHE-K): association with late-onset Alzheimer’s disease. Neurobiol. Aging 19, S69. 108. , et al. (1998) Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer’s disease and aging. Hum. Mol. Genet. 7, 933–935. 109. Singleton, A. , Gibson, A. , et al. (1998) No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer’s disease. Hum. Mol. Genet. 7, 937–939. 110. Montoya, S. , Aston, C.

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